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The duration of the rebound effect varies from person to person but generally lasts about one day. The elevated level of endorphins can result in an enhanced feeling of well-being as well as a reduction in pain and inflammation. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity. Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect in which both the production and utilization of OGF is greatly increased. As a consequence of this displacement, the affected cells becomeĭeficient in OGF and three things happen:ġ) Receptor production is increased, in order to try to capture more OGF.Ģ) Receptor sensitivity is increased, also to try to capture more OGF.ģ) Production of OGF is increased, in order to compensate for the perceived shortage of OGF. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF. In doing so, it displaces the endorphins which were previously bound to the receptors. Naltrexone is an orally administered drug that binds to opioid receptors. Endorphins resemble drugs like morphine, so when scientists first discovered these chemicals in the 1970s, they called them 'endogenous morphine'. It does this by binding to a receptor on the surface of the cells. Endorphins are natural chemicals in the body that fight pain.Endorphins are released when a person gets hurt, but also during exercise, laughter or sex.In addition to blocking pain, endorphins can make people happy. For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. The particular endorphin that has been found to influence cell growth is called Opioid Growth Factor (OGF). Disorders of the immune system, like autoimmune disorders, can occur with unusually low levels of endorphins. They are produced in most cells in the body and are important regulators of cell growth and the immune system. Endorphins are opiate-like molecules in the body. Before we discuss how LDN works, we need to go over the role of endorphins in the body.